Cross-translational models of late-onset cognitive sequelae and their treatment in pediatric brain tumor survivors

Al Dahhan Noor Z.; Cox Elizabeth; Nieman Brian J.Mabbott Donald J.

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Cross-translational models of late-onset cognitive sequelae and their treatment in pediatric brain tumor survivors

机译：Cross-translational models of late-onset cognitive sequelae and their treatment in pediatric brain tumor survivors

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Pediatric brain tumor treatments have a high success rate, but survivors are at risk of cognitive sequelae that impact long-term quality of life. We summarize recent clinical and animal model research addressing pathogenesis or evaluating candidate interventions for treatment-induced cognitive sequelae. Assayed inter-ventions encompass a broad range of approaches, including modifications to radiotherapy, modulation of immune response, prevention of treatment-induced cell loss or promotion of cell renewal, manipulation of neuronal signaling, and lifestyle/environmental adjustments. We further emphasize the potential of neuroi-maging as a key component of cross-translation to contextualize laboratory research within broader clinical findings. This cross-translational approach has the potential to accelerate discovery to improve pediatric cancer survivors' long-term quality of life.

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《Neuron》 |2022年第14期|2215-2241|共27页
作者
Al Dahhan Noor Z.; Cox Elizabeth; Nieman Brian J.Mabbott Donald J.;
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University of Toronto,Hosp Sick Children;

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正文语种英语
中图分类神经病学;
关键词
CENTRAL-NERVOUS-SYSTEM; OLIGODENDROCYTE PROGENITOR CELLS; ADULT HIPPOCAMPAL NEUROGENESIS; CHILDHOOD-CANCER SURVIVORS; RANDOMIZED CLINICAL-TRIAL; NEURAL PRECURSOR CELLS; LONG-TERM EFFICACY; WHITE-MATTER; RADIATION-THERAPY; CRANIAL IRRADIATION;

Cross-translational models of late-onset cognitive sequelae and their treatment in pediatric brain tumor survivors

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