Bioinspired antifouling and antibacterial polymer coating with intrinsic self-healing property

Anika Benozir Asha; Artjima Ounkaew; Yi-Yang PengMohammad Reza GholipourKazuhiko IshiharaYang LiuRavin Narain

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Bioinspired antifouling and antibacterial polymer coating with intrinsic self-healing property

机译：Bioinspired antifouling and antibacterial polymer coating with intrinsic self-healing property

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Infections caused by biofouling have become a serious concern in the health care sector. Multifunctional coatings with antifouling and antibacterial properties are widely used to combat these biofouling related infections. However, in practice macro or micro scratches or damages can happen to the coating, which can act as an active site for microbial deposition and destroy the antifouling or antibacterial functionality of the coating. Considering this fact, we have developed an excellent biocompatible and multifunctional coating with antifouling, antibacterial and self-healing properties. In this study, prebiotic chemistry inspired self-polymerization of aminomalononitrile (AMN) was used as a primary coating layer, which acted as a primer to graft vitamin B5 analogous methacrylamide polymer poly(B5AMA) and zwitterionic compound 2-methacryloyloxyethyl phosphorylcholine (MPC) containing polymer poly (MPC-st-B5AMA) by forming strong hydrogen bonds. B5AMA having multiple polar groups in the structure acted as an intrinsic self-healing material and showed an excellent antifouling property against protein and bacteria, maintaining a good hydration layer similar to the MPC containing polymer. To impart the antibacterial property to the coating, silver nanoparticles have also been incorporated, which showed more than 90 killing efficiency against both Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli) bacteria with significant reduction of their adhesion on the surface. Incorporation of self-healing property into the fouling repelling and antibacterial coating can significantly extend the durability of the multifunctional coating, making it promising for biomedical applications.

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《Biomaterials Science》 |2023年第1期|128-139|共12页
作者
Anika Benozir Asha; Artjima Ounkaew; Yi-Yang PengMohammad Reza GholipourKazuhiko IshiharaYang LiuRavin Narain;
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Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta T6G 2G6, Canada;

Anton Paar Canada Inc., 4920 Place Olivia, Montreal, Quebec, H4R 2Z8, Canada;

Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, JapanDepartment of Civil and Environment Engineering, University of Alberta, Edmonton, Alberta T6G 2G6, Canada;

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中图分类计量学;
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Bioinspired antifouling and antibacterial polymer coating with intrinsic self-healing property

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