International validation of the EORTC CAT Core: a new adaptive instrument for measuring core quality of life domains in cancer

Petersen Morten Aa; Aaronson Neil K.; Conroy ThierryCostantini AnnaGiesinger Johannes M.Hammerlid EvaHolzner BernhardJohnson Colin D.Kieffer Jacobien M.van Leeuwen MariekeNolte SandraRamage John K.Tomaszewski Krzysztof A.Waldmann AnnikaYoung TeresaZotti PaolaGroenvold Mogens

首页> 外文期刊>Quality of life research: An international journal of quality of life aspects of treatment, care and rehabilitation >International validation of the EORTC CAT Core: a new adaptive instrument for measuring core quality of life domains in cancer

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International validation of the EORTC CAT Core: a new adaptive instrument for measuring core quality of life domains in cancer

机译：International validation of the EORTC CAT Core: a new adaptive instrument for measuring core quality of life domains in cancer

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Background The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group (QLG) has developed computerised adaptive tests (CATs) for the 14 functional and symptom domains of the EORTC QLQ-C30 quality of life questionnaire. This is expected to optimise measurement precision, relevance to patients and flexibility. Here, we present the first international validation of the EORTC CAT Core. Methods A heterogeneous sample of 699 cancer patients scheduled for chemotherapy and/or radiotherapy was recruited across seven European countries. The EORTC CAT Core and all QLQ-C30 items were administered to participants before and after initiating treatment. Correlations between CAT and QLQ-C30 scores and floor/ceiling effects were calculated. Using several grouping variables, relative validity (cross-sectional known groups difference), responsiveness (changes over time) and relative sample size requirements of the CAT compared to the QLQ-C30 were estimated. Results Correlations of the CAT and QLQ-C30 ranged from 0.81 to 0.93 across domains. The mean relative reduction in floor and ceiling effects using the CAT was 42 (range 3-99). Analyses of known groups validity and responsiveness indicated that, across domains, mean sample size requirements for the CAT were 72 and 70, respectively, of those using the QLQ-C30. Conclusions The EORTC CAT Core measures the same domains as the QLQ-C30 with reduced floor/ceiling effects. The CAT generally facilitated the use of smaller samples (about 30 smaller on average) without loss of power compared to the QLQ-C30. Based on this study, the EORTC QLG will release the EORTC CAT Core for general use.

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《Quality of life research: An international journal of quality of life aspects of treatment, care and rehabilitation》 |2020年第5期|1405-1417|共13页
作者
Petersen Morten Aa; Aaronson Neil K.; Conroy ThierryCostantini AnnaGiesinger Johannes M.Hammerlid EvaHolzner BernhardJohnson Colin D.Kieffer Jacobien M.van Leeuwen MariekeNolte SandraRamage John K.Tomaszewski Krzysztof A.Waldmann AnnikaYoung TeresaZotti PaolaGroenvold Mogens;
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Bispebjerg Bakke 23B, Bispebjerg & Frederiksberg Hosp, Dept Palliat Med, Res Unit, Bispebjerg Bakke;

Netherlands Canc Inst, Div Psychosocial Res & Epidemiol, Amsterdam, Netherlands;

Univ Lorraine, APEMAC, EA4360, Vandoeuvre Les Nancy, FranceSapienza Univ, St Andrea Hosp, Fac Med & Psychol, Psychoncol Unit, Rome, ItalyUniv Hosp Psychiat II, Dept Psychiat Psychotherapy & Psychosomat, Innsbruck, AustriaGothenburg Univ, Sahlgrenska Univ Hosp, Dept Otolaryngol Head & Neck Surg, Gothenburg, SwedenUniv Southampton, Fac Med, Surg Unit, Southampton, Hants, EnglandCharite Univ Med Berlin, Div Psychosomat Med, Med Dept, Berlin, GermanyHampshire Hosp NHS Trust, Kings Coll Hosp ENETS Ctr Excellence, Dept Gastroenterol, BasingstokeAndrzej Frycz Modrzewski Krakow Univ, Fac Med & Hlth Sci, Krakow, PolandUniv Lubeck, Inst Social Med & Epidemiol, Lubeck, GermanyEast & North Hertfordshire NHS Trust Incorporatin, Northwood, Middx, EnglandIRCCS, Sci Directorate, Ctr Riferimento Oncol Aviano CRO, Aviano, Italy;

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中图分类医药、卫生;
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International validation of the EORTC CAT Core: a new adaptive instrument for measuring core quality of life domains in cancer

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