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首页> 外文期刊>iranian journal of microbiology >Iodine induces toxicity against Candida albicans and Candida glabrata through oxidative stress
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Iodine induces toxicity against Candida albicans and Candida glabrata through oxidative stress

机译：Iodine induces toxicity against Candida albicans and Candida glabrata through oxidative stress

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Background and Objectives: Candida species are antifungal-resistant opportunistic infections that spread through contaminated medical staff hands and hospital surfaces creating a nosocomial infection risk. Iodine's antibacterial properties are well established; however, its antifungal properties remain unknown. The objective of this study was to investigate the antifungal effects of lugol on cell viability and oxidative stress on Candida albicans and Candida glabrata strains. Materials and Methods: MTT reduction test and sensitivity growth assay were used to determine viability and minimal inhibitory concentration, colorimetric tests were used to analyzing lipoperoxidation and antioxidant status in C. albicans, parental C. glabrata, C. glabrata lacking catalase gene (dal) and superoxide dismutase 1 and 2 double mutants (sod1 Delta sod2 Delta) strains exposure to lugol were used. Results: In both C. albicans and C. glabrata wild types lugol treatment decreased cellular viability in a dose-depaulent manna at 30 mm. The cytotoxic lugol effect was characterized by the increase of oxidative stress and the reduction of superoxide dismutase and catalase enzyme activities. C. glabrata strains lacking catalase (cta 1)and superoxide dismutase 1 and 2 double mutants (sod1 Delta sod2 Delta) were less resistant to lugol than parental C. glabrata strains. Conclusion: In Candida strains iodine lugol solution has antifungal properties, producing cytotox city and oxidative stress. Superoxide dismutase 1 and 2 activities are involved in resistance of Candida to iodine.

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