Optical coherence microscopy (OCM) is a high-resolution label-free imaging modality based on the combination of optical coherence tomography and confocal microscopy. Here, we review our recent progress on the development of high-resolution OCM in the third near-infrared (NIR-III) optical window (1550-1850 nm) for deep tissue imaging. Recent studies show that the use of NIR-III optical window allows us to achieve large imaging depth and high image contrast in tissue imaging. In our group, we developed three-dimensional (3D) high-resolution OCM system in the 1700 nm spectral band by using a high-power supercontinuum (SC) fiber laser source with 300-nm spectral bandwidth (full-width at halfmaximum) and demonstrated that deep tissue imaging at a depth up to 1.8 mm with high spatial resolution. We also demonstrated that the 1700-nm OCM system provides high axial resolution even in tissue specimens by only compensating chromatic dispersion mismatching between sample and reference arm.
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