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首页> 外文期刊>Vaccine >Neutralizing antibody responses in healthcare personnel after three doses of mRNA BNT162b2 vaccine and association with baseline characteristics and past SARS-CoV-2 infection
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Neutralizing antibody responses in healthcare personnel after three doses of mRNA BNT162b2 vaccine and association with baseline characteristics and past SARS-CoV-2 infection

机译：Neutralizing antibody responses in healthcare personnel after three doses of mRNA BNT162b2 vaccine and association with baseline characteristics and past SARS-CoV-2 infection

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Aim: To estimate neutralizing antibody (NAb) immunity against SARS-CoV-2 in 739 healthcare personnel (HCP) vaccinated with three doses of BNT162b2 mRNA vaccine.Methods: Serum samples were collected at 3, 6, and 9 months after the second vaccine dose and at 7- 55 days after the third dose. Samples were tested for NAbs against SARS-CoV-2 receptor binding domain.Results: The mean inhibition rates at 3, 6, and 9 months after the second dose were 86.33, 73.38, and 61.18, and increased to 95.57 after the booster dose. Younger HCP and HCP with past SARS-CoV-2 infection had higher inhibition rates while there was an inverse correlation between NAb levels and comorbidities or tobacco use (p-values < 0.001). Increased NAb titers were also noticed in women (p -value = 0.033), especially at the end of the 9-month study period.Conclusion: NAb levels increased considerably after a booster mRNA vaccine dose. Host factors and past SARS-CoV-2 infection influence NAb titers.(c) 2022 Elsevier Ltd. All rights reserved.

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