Contribution of PER-Type and NDM-Type beta-Lactamases to Cefiderocol Resistance in Acinetobacter baumannii

Poirel Laurent; Sadek Mustafa; Nordmann Patrice

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Contribution of PER-Type and NDM-Type beta-Lactamases to Cefiderocol Resistance in Acinetobacter baumannii

机译：Contribution of PER-Type and NDM-Type beta-Lactamases to Cefiderocol Resistance in Acinetobacter baumannii

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Cefiderocol (FDC) is a recently developed siderophore cephalosporin showing excellent antibacterial activity against Gram-negative bacteria, including Acinetobacter baumannii. By investigating a series of A. baumannii clinical isolates with elevated MICs of FDC, we showed that PER-like beta-lactamases and, to a lesser extent, NDM-like beta-lactamases, significantly contributed to reduced susceptibility to that antibiotic. Interestingly, we showed that combination of FDC with avibactam exhibited excellent activity against all multidrug-resistant isolates coproducing OXA-23 and PER-type beta-lactamases.

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《Antimicrobial agents and chemotherapy.》 |2021年第10期|共5页
作者
Poirel Laurent; Sadek Mustafa; Nordmann Patrice;
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作者单位

Univ Fribourg, Fac Sci & Med, Med & Mol Microbiol, Fribourg, Switzerland;

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原文格式 PDF
正文语种英语
中图分类治疗学;
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cefiderocol; Acinetobacter baumannii; susceptibility testing; PER-type beta-lactamase; NDM; PER; beta-lactamase;

Contribution of PER-Type and NDM-Type beta-Lactamases to Cefiderocol Resistance in Acinetobacter baumannii

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