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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America. >A proposed unified mitotic chromosome architecture
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A proposed unified mitotic chromosome architecture

机译：A proposed unified mitotic chromosome architecture

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摘要

A molecular architecture is proposed for a representative mitotic chromosome, human chromosome 10. This architecture is built on an interphase chromosome structure based on cryo-electron microscopy (cryo-EM) cellular tomography J. Sedat et al., Proc. Natl. Acad. Sci. U.S.A., in press, thus unifying chromosome structure throughout the complete mitotic cycle. The basic organizational principle for mitotic chromosomes is specific coiling of the 11-nm nucleosome fiber into large scale, ～200-nm interphase structures, a Slinky https://en.wikipedia.org/wiki/Slinky; motif cited in S. Bowerman et al., eLife 10, e65587 (2021), then further modified with subsequent additional coiling for the final mitotic chromosome structure. The final mitotic chromosome architecture accounts for the dimensional values as well as the well-known cytological configurations. In addition, proof is experimentally provided by digital PCR technology that G1 T cell nuclei are diploid with one DNA molecule per chromosome. Many nucleosome linker DNA sequences, the promotors and enhancers, are suggestive of optimal exposure on the surfaces of the large-scale coils. Copyright ? 2022 the Author(s).

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