The etiology of inflammatory and autoimmune diseases is complex and not yet fully understood Their pathogenesis includes mechanisms in which both innate and adaptive immune cells are involved. Mucosal-associated invariant T (MAIT) cells are immune cells expressing an invariant TCRalpha chain (Valpha7.2-Jalpha33 in human and Val9-Ja33 in mice) and recognize the conserved MHC-I-related molecule MR1, which presents bacterial metabolites derived from the synthesis of vitamin B. Although most of the studies support a hazardous role of MAIT cells in tissue inflammation and destruction, few studies suggest a protective role. MATT cells have tissue homing properties with the production of inflammatory cytokines, signifying that they may play an essential role in autoimmune and inflammatory diseases. In the current study, we clarified the present knowledge on MAIT cells in systemic lupus erythematosus.
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