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首页> 外文期刊>Bulletin of pharmaceutical sciences >IMPACT OF INFECTION WITH HELICOBACTER PYLORI ON INTERLEUKIN-10 MRNA EXPRESSION IN STOMACH MUCOSA
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IMPACT OF INFECTION WITH HELICOBACTER PYLORI ON INTERLEUKIN-10 MRNA EXPRESSION IN STOMACH MUCOSA

机译：IMPACT OF INFECTION WITH HELICOBACTER PYLORI ON INTERLEUKIN-10 MRNA EXPRESSION IN STOMACH MUCOSA

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摘要

The immuno-regulatory cytokine interleukin 10 (IL-10) is important in reducing the inflammatory response during H. pylori infection. The goal of our study was to explain how H.pylori infection affects mucosal IL-10 mRNA expression. This study included seventy-three patients suffering from gastroduodenal disorders admitted to Assiut University Hospitals, (35 (47.95) were males, and 38 (52.05) were females). Three antral biopsies were obtained from each patient during endoscopic examination. Two invasive tests (Rapid urease test (RUT) and polymerase chain reaction (PCR)) were performed for the detection of H.pylori infection in all participants. Real time PCR (RT-PCR) was performed for determination of IL-10 mRNA expression. Results of RUT and PCR indicated that 60.27 of patients were H. pylori infected. Our results showed that patients positive for H. pylori had significantly higher 1L10 mRNA expression than H. pylori-negative patients. Finally, overexpression of IL-10 during H. Pylori infection may be implicated in the downregulation of excessive immune response.

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