Inter/Transgenerational Effects of Drugs of Abuse: A Scoping Review

Mitra-Sadat Sadat-Shirazi; Mahsa Sadeghi-Adl; Ardeshir AkbarabadiGhorbangol AshabiAzarakhsh MokriMohammad-Reza Zarrindast

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Inter/Transgenerational Effects of Drugs of Abuse: A Scoping Review

机译：Inter/Transgenerational Effects of Drugs of Abuse: A Scoping Review

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Drug addiction is a chronic relapsing disorder that makes it a global problem. Genetics and environmental factors are the two most important factors that make someone vulnerable to drug addiction. Investigations in the past decade highlighted the role of epigenetics in the inter/transgenerational inheritance of drug addiction. A growing body of evidence showed that parental (paternal, maternal, and biparental) drug exposure before conception changes the phenotype of the offspring, which is correlated with neurochemical and neurostructural changes in the brain. The current paper reviews the effects of parental (maternal, paternal, and biparental) exposure to drugs of abuse (opioids, cocaine, nicotine, alcohol, and cannabis) before gestation in animal models.

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来源
《CNS & neurological disorders drug targets》 |2023年第4期|512-538|共27页
作者
Mitra-Sadat Sadat-Shirazi; Mahsa Sadeghi-Adl; Ardeshir AkbarabadiGhorbangol AshabiAzarakhsh MokriMohammad-Reza Zarrindast;
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作者单位

Iranian National Center for Addiction Studies, Tehran University of Medical Sciences,Tehran,Iran,;

School of Medicine, Tehran University of Medical Sciences,Department of Physiology,Tehran,Iran,;

Iranian National Center for Addiction Studies, Tehran University of Medical Sciences,Tehran,Iran;

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正文语种英语
中图分类神经病学与精神病学;
关键词
Transgeneration; opioid; cocaine; cannabis; nicotine; ethanol; parental.;

Inter/Transgenerational Effects of Drugs of Abuse: A Scoping Review

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