Palladium-Catalyzed C-H Olefination for Nucleic Acid Production

Ruoqian Xie; Yunxi Han; Wenhao LuoQin ZhaoYangyan LiGang Chen

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Palladium-Catalyzed C-H Olefination for Nucleic Acid Production

机译：Palladium-Catalyzed C-H Olefination for Nucleic Acid Production

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摘要

The palladium-catalyzed direct C-H olefination of unprotected uridine, 2'-deoxyuridine, uridine monophosphate, and uridine analogues are described here. This protocol provides an efficient, atom-economical, and environmentally friendly method for the introduction of an alkenyl group at the C5 position of the uracil without pre-functionalization. A series of C5-alkenylated uridine analogues, including some biologically significant compounds and potential pharmaceutical candidates, were synthesized with exposed hydroxyl groups on the ribose.

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来源
《Current Protocols in Nucleic Acid Chemistry》 |2023年第7期|e829-1-e829-11|共11页
作者
Ruoqian Xie; Yunxi Han; Wenhao LuoQin ZhaoYangyan LiGang Chen;
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作者单位

Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, People's Republic of China;

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原文格式 PDF
正文语种英语
中图分类生物化学;
关键词
C-H olefination; late-stage functionalization; nucleoside analogues; Pd-catalyzed; uridine;

Palladium-Catalyzed C-H Olefination for Nucleic Acid Production

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