Response assessment in pediatric craniopharyngioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) Working Group

Lindsey M. Hoffman; Camilo Jaimes; Kshitij MankadDavid M. MirskyBenita TamraziChristopher L. TinkleCassie KlineAparna RamasubramanianFatema MalbariRoss MangumHolly LindsayVincent HomeDavid J. DanielsSameer KeoleDavid R. GrosshansTina Young PoussaintRoger PackerSergio CavalheiroBrigitte BisonTodd C. HankinsonHermann L. MuellerUte BartelsKatherine E. WarrenMurali Chintagumpala

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Response assessment in pediatric craniopharyngioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) Working Group

机译：Response assessment in pediatric craniopharyngioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) Working Group

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Background. Craniopharyngioma is a histologically benign tumor of the suprasellar region for which survival is excellent but quality of life is often poor secondary to functional deficits from tumor and treatment. Standard therapy consists of maximal safe resection with or without radiation therapy. Few prospective trials have been performed, and response assessment has not been standardized. Methods. The Response Assessment in Pediatric Neuro-Oncology (RAPNO) committee devised consensus guidelines to assess craniopharyngioma response prospectively. Results. Magnetic resonance imaging is the recommended radiologic modality for baseline and follow-up assessments. Radiologic response is defined by 2-dimensional measurements of both solid and cystic tumor components. In certain clinical contexts, response to solid and cystic disease may be differentially considered based on their unique natural histories and responses to treatment. Importantly, the committee incorporated functional endpoints related to neuro-endocrine and visual assessments into craniopharyngioma response definitions. In most circumstances, the cystic disease should be considered progressive only if growth is associated with acute, new-onset or progressive functional impairment. Conclusions. Craniopharyngioma is a common pediatric central nervous system tumor for which standardized response parameters have not been defined. A RAPNO committee devised guidelines for craniopharyngioma assessment to uniformly define response in future prospective trials.

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《Neuro-oncology》 |2023年第2期|224-233|共10页
作者
Lindsey M. Hoffman; Camilo Jaimes; Kshitij MankadDavid M. MirskyBenita TamraziChristopher L. TinkleCassie KlineAparna RamasubramanianFatema MalbariRoss MangumHolly LindsayVincent HomeDavid J. DanielsSameer KeoleDavid R. GrosshansTina Young PoussaintRoger PackerSergio CavalheiroBrigitte BisonTodd C. HankinsonHermann L. MuellerUte BartelsKatherine E. WarrenMurali Chintagumpala;
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Department of Pediatrics, Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Canada;

Division of Pediatric Neuro-Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA;

Division of Hematology-Oncology, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas, USACenter for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, Arizona, USADepartment of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USADepartment of Radiology, Great Ormond Street Hospital for Children, London, UKDepartment of Radiology, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado, USADepartment of Radiology, Children's Hospital Los Angeles, Los Angeles, California, USADepartment of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USADivision of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USADepartment of Ophthalmology, Phoenix Children's Hospital, Phoenix, Arizona, USADivision of Neurology and Developmental Neurosciences, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas, USADivision of Pediatric Diabetes and Endocrinology, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas, USADepartment of Neurosurgery, Mayo Clinic, Rochester, Minnesota, USADepartment of Radiation Oncology, Mayo Clinic, Phoenix, Arizona, USADepartment of Radiation Oncology, MD Anderson Cancer Center, Houston, Texas, USACenter for Neuroscience and Behavioral Medicine, Brain Tumor Institute, Washington, District of Columbia, USAPediatric Oncology Institute, Federal University of Sao Paulo, Sao Paulo, BrazilDiagnostic and Interventional Neuroradiology, Faculty of Medicine, University Hospital Augsburg, Augsburg, GermanyDepartment of Neurosurgery, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO, USADepartment of Pediatrics and Pediatric Hematology/Oncology, University Children's Hospital, Klinikum Oldenburg AoeR, Carl von Ossietzky University Oldenburg, 26133 Oldenburg, Germany;

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craniopharyngioma; functional; pediatric; response;

Response assessment in pediatric craniopharyngioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) Working Group

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