A dual-modal ROS generator based on multifunctional PDA–MnO2@Ce6 nanozymes for synergistic chemo-photodynamic antibacterial therapy

Cui Anni; Bao Ying; Xu HaitaoMu XinZhong XiahuaWee WynnWu FanqiShan Guiye

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A dual-modal ROS generator based on multifunctional PDA–MnO2@Ce6 nanozymes for synergistic chemo-photodynamic antibacterial therapy

机译：A dual-modal ROS generator based on multifunctional PDA–MnO2@Ce6 nanozymes for synergistic chemo-photodynamic antibacterial therapy

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The rapid emergence of drug-resistant bacteria has attracted great attention to exploring advanced antibacterial methods. However, single-modal antibacterial therapy cannot easily eliminate drug-resistant bacteria completely due to its low efficacy. Therefore, it is essential to achieve multi-modal antibacterial therapy effectively. Herein, a dual-modal ROS generator was designed based on photosensitive PDA–MnO2@Ce6/liposome (PMCL) nanozymes for synergistic chemo-photodynamic therapy. PMCL nanozymes adhere to bacteria through liposome–membrane fusion. Meanwhile, PMCL catalyzes endogenous hydrogen peroxide (H2O2) to generate hydroxyl radicals (˙OH) and singlet oxygen (1O2) under laser irradiation. Furthermore, the photothermal effect can accelerate the generation of ROS. Based on dual-enzyme activities (mimicking peroxidase and catalase) and photodynamic properties, PMCL achieves powerful antibacterial efficacy and mature bacterial biofilm eradication. With the synergistic chemo-photodynamic effects, bacterial populations decrease by >99.76 against Gram-positive S. aureus and Gram-negative E. coli. Notably, the synergistic antibacterial properties of PMCL nanozymes are further explored using a mouse wound model of S. aureus infection. This work fabricated an efficient dual-modal ROS generator to kill bacteria, further providing a new strategy for treating wound infection.

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来源
《Biomaterials Science》 |2023年第6期|2243-2252|共10页
作者
Cui Anni; Bao Ying; Xu HaitaoMu XinZhong XiahuaWee WynnWu FanqiShan Guiye;
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作者单位

Northeast Normal University;

Western Washington University;

the Second Hospital of Jilin UniversityThompson Rivers University;

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正文语种英语
中图分类分子生物学;
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A dual-modal ROS generator based on multifunctional PDA–MnO2@Ce6 nanozymes for synergistic chemo-photodynamic antibacterial therapy

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