A Visible-Light-Promoted C-H Arylation and Heteroarylation of Uracil Derivatives with Diazoniums in Aqueous Conditions

An-Di Liu; Zhao-Li Wang; Li LiuLiang Cheng

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A Visible-Light-Promoted C-H Arylation and Heteroarylation of Uracil Derivatives with Diazoniums in Aqueous Conditions

机译：A Visible-Light-Promoted C-H Arylation and Heteroarylation of Uracil Derivatives with Diazoniums in Aqueous Conditions

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摘要

The photoredox synthesis of C-5 (hetero)arylated uracil and uridine substrates with the corresponding diazonium salts is described. The coupling proceeds efficiently without protection of the hydroxyls at the ribose or pre-functionalization of the C5 position at the nucleobase. No transition-metal catalyst is used in this transformation, thereby avoiding metal contamination in the final products. The use of water as the medium also eliminates the impurities caused by the use of organic solvents.

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《Current Protocols in Nucleic Acid Chemistry》 |2022年第6期|e432-1-e432-13|共13页
作者
An-Di Liu; Zhao-Li Wang; Li LiuLiang Cheng;
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作者单位

Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China;

Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China;

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正文语种英语
中图分类生物化学;
关键词
C-H arylation; diazonium salt; photoredox coupling; uracil; uridines;

A Visible-Light-Promoted C-H Arylation and Heteroarylation of Uracil Derivatives with Diazoniums in Aqueous Conditions

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