A core–shell liquid metal-Cu nanoparticle with glutathione consumption via an in situ replacement strategy for tumor combination treatment of chemodynamic, microwave dynamic and microwave thermal therapy

Yu Yongnian; Wu Qiong; Niu MengGou LiTan LongfeiFu ChanghuiRen XianglingRen JunZheng YongfaMeng Xianwei

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A core–shell liquid metal-Cu nanoparticle with glutathione consumption via an in situ replacement strategy for tumor combination treatment of chemodynamic, microwave dynamic and microwave thermal therapy

机译：A core–shell liquid metal-Cu nanoparticle with glutathione consumption via an in situ replacement strategy for tumor combination treatment of chemodynamic, microwave dynamic and microwave thermal therapy

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The presence of high content glutathione (GSH) provides an effective “protective shield” for tumor cells, which undoubtedly is a huge impediment to reactive oxygen species (ROS)-based treatment. Fortunately, divalent copper (Cu2+) can not only consume GSH, destroying the protection mechanism of GSH, but also can be reduced to Cu+ with excellent Fenton-like reaction activity. Hence, capitalizing on the properties of liquid metals, we introduced Cu with three different valances via an in situ replacement reaction. A stable core–shell liquid-metal based “Cu storage pool” was obtained. It can effectively deplete GSH within the cells, and simultaneously produce ·OH through a Fenton-like reaction, further improving the effect of chemodynamic therapy (CDT). Under microwave irradiation, it is also capable of producing a large amount of ROS to promote tumor treatment. In addition, the loading of ionic liquid endows LZC@IL nanoparticles with certain microwave heating performance, which is able to augment microwave thermal therapy (MWTT). With the combination of CDT, microwave dynamic therapy (MDT) and MWTT, LZC@IL has an excellent effect on tumor elimination. This work offers a new idea for the application of liquid metals and the combined treatment of tumors, which has potential application value.

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来源
《Biomaterials Science》 |2022年第13期|3503-3513|共11页
作者
Yu Yongnian; Wu Qiong; Niu MengGou LiTan LongfeiFu ChanghuiRen XianglingRen JunZheng YongfaMeng Xianwei;
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作者单位

Sichuan University;

Chinese Academy of Sciences;

First Hospital of China Medical UniversityRenmin Hospital of Wuhan University;

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正文语种英语
中图分类分子生物学;
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A core–shell liquid metal-Cu nanoparticle with glutathione consumption via an in situ replacement strategy for tumor combination treatment of chemodynamic, microwave dynamic and microwave thermal therapy

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