Office blood pressure threshold of 130/80 mmHg better predicts uncontrolled out‐of‐office blood pressure in apparent treatment‐resistant hypertension

Chan Joo Lee; Jeong‐Ha Ha; Jang Young KimIn‐Cheol KimSung Kee RyuMoo‐Yong RheeJu‐Hee LeeJung‐Hee LeeHae‐Young LeeSang‐Hyun IhmJoong Wha ChungJung Hyun ChoiJinho ShinSungha ParkKazuomi Kario

首页> 外文期刊>The journal of clinical hypertension. >Office blood pressure threshold of 130/80 mmHg better predicts uncontrolled out‐of‐office blood pressure in apparent treatment‐resistant hypertension

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Office blood pressure threshold of 130/80 mmHg better predicts uncontrolled out‐of‐office blood pressure in apparent treatment‐resistant hypertension

机译：Office blood pressure threshold of 130/80 mmHg better predicts uncontrolled out‐of‐office blood pressure in apparent treatment‐resistant hypertension

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The objective of this study was to compare the diagnostic accuracy of office blood pressure (BP) threshold of 140/90 and 130/80 mmHg for correctly identifying uncontrolled out‐of‐office BP in apparent treatment‐resistant hypertension (aTRH). We analyzed 468 subjects from a prospectively enrolled cohort of patients with resistant hypertension in South Korea (clinicaltrials.gov: NCT03540992). Resistant hypertension was defined as office BP ≥ 130/80 mmHg with three different classes of antihypertensive medications including thiazide‐type/like diuretics, or treated hypertension with four or more different classes of antihypertensive medications. We conducted different types of BP measurements including office BP, automated office BP (AOBP), home BP, and ambulatory BP. We defined uncontrolled out‐of‐office BP as daytime BP ≥ 135/85 mmHg and/or home BP ≥ 135/85 mmHg. Among subjects with office BP 140/90 mmHg and subjects with office BP 130/80 mmHg, 66 and 55 had uncontrolled out‐of‐office BP, respectively. The prevalence of controlled and masked uncontrolled hypertension was lower, and the prevalence of white‐coat and sustained uncontrolled hypertension was higher, with a threshold of 130/80 mmHg than of 140/90 mmHg, for both office BP and AOBP. The office BP threshold of 130/80 mmHg was better able to diagnose uncontrolled out‐of‐office BP than 140/90 mmHg, and the net reclassification improvement (NRI) was 0.255. The AOBP threshold of 130/80 mmHg also revealed better diagnostic accuracy than 140/90 mmHg, with NRI of 0.543. The office BP threshold of 130/80 mmHg showed better than 140/90 mmHg in terms of the correspondence to out‐of‐office BP in subjects with aTRH.

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《The journal of clinical hypertension.》 |2021年第3期|595-605|共11页
作者
Chan Joo Lee; Jeong‐Ha Ha; Jang Young KimIn‐Cheol KimSung Kee RyuMoo‐Yong RheeJu‐Hee LeeJung‐Hee LeeHae‐Young LeeSang‐Hyun IhmJoong Wha ChungJung Hyun ChoiJinho ShinSungha ParkKazuomi Kario;
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Division of Cardiology Severance Cardiovascular Hospital Yonsei University College of Medicine Seoul Korea;

Department of Health Promotion Severance Hospital Yonsei University College of Medicine Seoul Korea;

Department of Internal Medicine Wonju College of Medicine Yonsei University Wonju KoreaDivision of Cardiology Department of Internal Medicine Cardiovascular Center Keimyung University Dongsan Hospital Keimyung University College of Medicine Daegu KoreaDivision of Cardiology Department of Internal Medicine Eulji General Hospital Eulji University School of Medicine Seoul KoreaCardiovascular Center College of Medicine Dongguk University Ilsan Hospital Dongguk University Goyang KoreaDivision of Cardiology Department of Internal Medicine Chungbuk National University Hospital Chungbuk National University College of Medicine Cheongju KoreaDivision of Cardiology Yeungnam University Medical Center Yeungnam University College of Medicine Daegu KoreaDepartment of Internal Medicine Seoul National University Hospital Seoul KoreaDivision of Cardiology Department of Internal Medicine Bucheon St. Mary's Hospital, College of Medicine The Catholic University of Korea Seoul KoreaDepartment of Internal Medicine Chosun University School of Medicine Kwangju KoreaDivision of Cardiology Department of Internal Medicine Pusan National University Hospital Pusan National University School of Medicine Busan KoreaDivision of Cardiology Department of Internal Medicine College of Medicine Hanyang University Seoul KoreaCardiovascular Research Institute Yonsei University College of Medicine Seoul KoreaDivision of Cardiovascular Medicine Department of Medicine Jichi Medical University School of Medicine Tochigi Japan;

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office blood pressure; out‐of‐office blood pressure; resistant hypertension;

Office blood pressure threshold of 130/80 mmHg better predicts uncontrolled out‐of‐office blood pressure in apparent treatment‐resistant hypertension

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