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首页> 外文期刊>Electroanalysis >Sensor Modified with Gold Nanoparticles Stabilized in Dialdehyde Starch/DMSO Matrix for Methyldopa Detection
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Sensor Modified with Gold Nanoparticles Stabilized in Dialdehyde Starch/DMSO Matrix for Methyldopa Detection

机译：Sensor Modified with Gold Nanoparticles Stabilized in Dialdehyde Starch/DMSO Matrix for Methyldopa Detection

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摘要

In this study, gold nanoparticles (AuNP) were synthesized using a novel stabilizer based on dialdehyde starch polymer (DAS) and dimethyl sulfoxide (DMSO) and the nanomaterial was applied to develop a sensor for methyldopa detection. The nanoparticles were characterized by transmission electron microscopy and the proposed sensor was electrochemically characterized by electrochemical impedance spectroscopy, chronocoulometry and square-wave voltammetry. Under optimized conditions (0.1 molL(-1) McIlvaine buffer solution at pH 3.5 and 50 mu L AuNP/DAS-DMSO), using square- wave voltammetry, the calibration curve presented a linear range of 0.99 to 19.60 mu molL 1, with a detection limit of 0.50 mu molL(-1). The sensor showed good accuracy, with coefficients of variation of 7.8 (inter-day; n= 6) and 5.9 (intra-day; n= 3), and recovery values in the range of 95.3 to 105.2. The methyldopa content in a pharmaceutical sample was determined and the results show good correlation with the label value and the method recommended by the Pharmacopoeia, representing a fast and accurate alternative for detecting methyldopa in pharmaceutical products.

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