Comparative Accuracy of Clinical Fibrosis Markers, Hepascore and Fibroscan? to Detect Advanced Fibrosis in Patients with Nonalcoholic Fatty Liver Disease

Luis C.Bertot; Gary P.Jeffrey; Bastiaande BoerZhengyiWangYiHuangGeorgeGarasGerryMacQuillanMichaelWallaceBriohny W.SmithLeon A.Adams

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Comparative Accuracy of Clinical Fibrosis Markers, Hepascore and Fibroscan? to Detect Advanced Fibrosis in Patients with Nonalcoholic Fatty Liver Disease

机译：Comparative Accuracy of Clinical Fibrosis Markers, Hepascore and Fibroscan? to Detect Advanced Fibrosis in Patients with Nonalcoholic Fatty Liver Disease

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Abstract Background Non-invasive tests are widely used to diagnose fibrosis in patients with non-alcoholic fatty liver disease (NAFLD), however, the optimal method remains unclear. We compared the accuracy of simple serum models, a serum model incorporating direct measures of fibrogenesis (Hepascore), and Fibroscan?, for detecting fibrosis in NAFLD.Methods NAFLD patients undergoing liver biopsy were evaluated with Hepascore, NAFLD Fibrosis Score (NFS), FIB-4 and AST-platelet ratio index (APRI), with a subset (n?=?131) undergoing Fibroscan?. Fibrosis on liver biopsy was categorized as advanced (F3–4) or cirrhosis (F4). Accuracy was determined by area under receiving operating characteristic curves (AUC). Indeterminate ranges were calculated using published cut-offs.Results In 271 NAFLD patients, 83 (31) had F3–4 and 47 (17) cirrhosis. 6/131 (4) had an unreliable Fibroscan?. For the detection of advanced fibrosis, the accuracy of Hepascore (AUC 0.88) was higher than FIB-4 (0.73), NFS (0.72) and APRI (0.69) (p?

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《Digestive Diseases and Sciences》 |2023年第6期|2757-2767|共11页
作者
Luis C.Bertot; Gary P.Jeffrey; Bastiaande BoerZhengyiWangYiHuangGeorgeGarasGerryMacQuillanMichaelWallaceBriohny W.SmithLeon A.Adams;
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作者单位

Medical School,University of Western Australia, QEII Medical Campus;

Department of Anatomical Pathology, Pathwest,QEII Medical Campus;

Department of Hepatology,Sir Charles Gairdner Hospital, QEII Medical Campus;

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正文语种英语
中图分类消化系及腹部疾病;
关键词
Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Elastography; Diagnosis; Non-invasive fibrosis models; Liver biopsy;

Comparative Accuracy of Clinical Fibrosis Markers, Hepascore and Fibroscan? to Detect Advanced Fibrosis in Patients with Nonalcoholic Fatty Liver Disease

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