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首页> 外文期刊>Neuron >Cocaine shifts dopamine D2 receptor sensitivity to gate conditioned behaviors
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Cocaine shifts dopamine D2 receptor sensitivity to gate conditioned behaviors

机译：Cocaine shifts dopamine D2 receptor sensitivity to gate conditioned behaviors

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Cocaine addiction is a chronic, relapsing disorder characterized by maladaptation in the brain mesolimbic and nigrostriatal dopamine system. Although changes in the properties of D2-receptor-expressing medium spiny neurons (D2-MSNs) and connected striatal circuits following cocaine treatment are known, the contri-butions of altered D2-receptor (D2R) function in mediating the rewarding properties of cocaine remain un-clear. Here, we describe how a 7-day exposure to cocaine alters dopamine signaling by selectively reducing the sensitivity, but not the expression, of nucleus accumbens D2-MSN D2Rs via an alteration in the relative expression and coupling of G protein subunits. This cocaine-induced reduction of D2R sensitivity facilitated the development of the rewarding effects of cocaine as blocking the reduction in G protein expression was sufficient to prevent cocaine-induced behavioral adaptations. These findings identify an initial maladaptive change in sensitivity by which mesolimbic dopamine signals are encoded by D2Rs following cocaine exposure.

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