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Metabolism-Driven Disassembly of Nanoprobes for Bacterial Detection, Imaging, and Photo-Inactivation

机译：Metabolism-Driven Disassembly of Nanoprobes for Bacterial Detection, Imaging, and Photo-Inactivation

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摘要

Bacterial infections have posed a grave challenge to public health. Molecular fluorescent probes play increasing important roles in diagnosis and treatment of bacterial infections, but are frequently hindered by the aggregation-caused quenching and low bacterial specificity as well as reduced bactericidal activity. Herein, metabolism-driven nanoprobes (HF-D-Ala NPs) are reported for bacteria-activated detection and following visible-light induced inactivation. The nanoprobes are formed via facile self-assembly of amphiphilic fluorescent small molecule (HF-D-Ala), showing strongly quenched fluorescence and enhanced photostability due to the dense aggregation of hydrophobic structural units. Once encountering with bacteria, HF-D-Ala NPs are disassembled into free HF-D-Ala, which can be further integrated into cell walls via bacterial metabolism. This progress can readily "turn-on" the molecular fluorescence, realizing visual bacterial detection and imaging. Subsequently, the labeled bacteria can be effectively inactivated by carbon monoxide released from incorporated HF-D-Ala upon visible-light. With good specificity and biocompatibility, HF-D-Ala NPs can selectively detect and inactivate bacteria in biofilms and bacteria co-existing with mammalian cells, showing great potential for bacterial infection theranostic applications.

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