In recent years, the amount of information available from formalin-fixed, paraffin-embedded (FFPE) samples, including transcriptome and proteome, has increased dramatically, and the field of pathogenesis research has undergone a major revolution. The authors have recently discovered that hyperspectral fluorescence imaging has the potential to detect amyloid-β lesions in squirrel monkey brains without labeling. This technique can specifically identify amyloid on FFPE specimens without specific antibodies or probes and is expected to establish a mechanical diagnostic technique by setting up a measurement model. The advantage of amyloid imaging based on autofluorescence is that it is possible to observe amyloid without labeling, and the same sample can be used for other analyses in its original state. This paper introduces the current status and future prospects of hyperspectral pathology imaging, referring to experimental data on amyloid detection promoted by the author.
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