Cytogenesis Effects on Sub-chronic administration of Cypermethrin in Albino Wistar Rats by different Mammalian Bio-assays

Shasta Kalra; Gurinder Kaur Sangha

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Cytogenesis Effects on Sub-chronic administration of Cypermethrin in Albino Wistar Rats by different Mammalian Bio-assays

机译：Cytogenesis Effects on Sub-chronic administration of Cypermethrin in Albino Wistar Rats by different Mammalian Bio-assays

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摘要

The cytogenotoxic effects of cypermethrin on bone marrow cells and lymphocytes of Wistar rats are reported. During four weeks of experimentation, cypermethrin admistration at 1/25th and 1/50th of LD50 by oral intubation showed a dose-dependent increase in the frequency of sister chromatid exchange (SCEs) and micro-nucleated cells. A dose dependent increase in chromosomal aberrations like fragmentation, breakage and gaps in all the treated rats was ovserved. Increased tail length of lymphocytic comets in treated rats revealed that chronic exposure of cypermethrin resulted in carcinogenic and mutagenic effects.

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来源
《Pesticide Research Journal》 |2021年第2期|25-34|共10页
作者
Shasta Kalra; Gurinder Kaur Sangha;
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作者单位

Department of Zoology, Punjab Agricultural University, Ludhiana 141 004, Punjab, India;

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原文格式 PDF
正文语种英语
中图分类植物保护;
关键词
Cypermethrin; chromosomal aberrations; comet assay; genotoxicity; micronucleus; sister chromatid exchange;

Cytogenesis Effects on Sub-chronic administration of Cypermethrin in Albino Wistar Rats by different Mammalian Bio-assays

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