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机译:Evolution of insulin at the edge of foldability and its medical implications
Dept Biochem,Case Western Reserve Univ;
Dept Endocrinol & Metab,Tianjin Med Univ;
Dept Biochem & Mol Biol,Indiana Univ Sch MedDiv Metab Endocrinol & Diabet,Univ Michigan;
evolutionary medicine; unfolded protein response; protein structure; protein folding; folding efficiency; GROWTH-FACTOR-I; ENDOPLASMIC-RETICULUM; PROTEIN-STRUCTURE; DIABETES-MELLITUS; MUTANT PROINSULIN; RECEPTOR-BINDING; DISULFIDE BONDS; GENE-MUTATIONS; NMR METHODS; CHAIN;