Lysophosphatidic acid receptor type‐1 mediates brain activation in micro‐positron emission tomography analysis in a fibromyalgia‐like mouse model

Hiroyuki Neyama; Michiko Nishiyori; Yilong CuiYasuyoshi WatanabeHiroshi Ueda

首页> 外文期刊>The European journal of neuroscience. >Lysophosphatidic acid receptor type‐1 mediates brain activation in micro‐positron emission tomography analysis in a fibromyalgia‐like mouse model

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Lysophosphatidic acid receptor type‐1 mediates brain activation in micro‐positron emission tomography analysis in a fibromyalgia‐like mouse model

机译：Lysophosphatidic acid receptor type‐1 mediates brain activation in micro‐positron emission tomography analysis in a fibromyalgia‐like mouse model

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Abstract The intermittent cold stress‐induced generalized pain response mimics the pathophysiological and pharmacotherapeutic features reported for fibromyalgia patients, including the presence of chronic generalized pain and female dominance. In addition, the intermittent cold stress‐induced generalized pain is abolished in lysophosphatidic acid receptor type‐1 knockout mice, as reported in many cases of neuropathic pain models. This study aimed to identify the brain loci involved in the intermittent cold stress generalized pain response and test their dependence on the lysophosphatidic acid receptor type‐1. Positron emission tomography analyses using 2‐deoxy‐2‐18Ffluoro‐d‐glucose in the presence of a pain stimulus showed that intermittent cold stress causes a significant increase in uptake in the ipsilateral regions, including the salience networking‐related anterior cingulate cortex and insular cortex and the cognition‐related hippocampus. A significant decrease was observed in the default mode network‐related posterior cingulate cortex. Almost these intermittent cold stress‐induced changes were abolished in lysophosphatidic acid receptor type‐1 knockout mice. There results suggest that the intermittent cold stress‐induced generalized pain response is mediated by the lysophosphatidic acid receptor type‐1 in specific brain loci related to salience networking and cognition, which may lead to further developments in the treatment of fibromyalgia.

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《The European journal of neuroscience.》 |2022年第3期|4224-4233|共10页
作者
Hiroyuki Neyama; Michiko Nishiyori; Yilong CuiYasuyoshi WatanabeHiroshi Ueda;
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作者单位

Department of Pharmacology and Therapeutic Innovation,Nagasaki University Institute of Biomedical;

Laboratory for Biofunction Dynamics Imaging,RIKEN Center for Biosystems Dynamics Research;

Laboratory for Pathophysiological and Health Science,RIKEN Center for Biosystems Dynamics Research;

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正文语种英语
中图分类神经病学与精神病学;
关键词
default mode network; fibromyalgia; lysophosphatidic acid receptor; microPET; salience network;

Lysophosphatidic acid receptor type‐1 mediates brain activation in micro‐positron emission tomography analysis in a fibromyalgia‐like mouse model

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