Amplitude of low frequency fluctuations during resting state fMRI in autistic children

Achuthan Smitha Karavallil; Coburn Kelly L.; Beckerson Meagan E.Kana Rajesh K.

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Amplitude of low frequency fluctuations during resting state fMRI in autistic children

机译：Amplitude of low frequency fluctuations during resting state fMRI in autistic children

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Resting state fMRI (rs-fMRI) provides an excellent platform for examining the amplitude of low frequency fluctuations (ALFF) and fractional amplitude of low frequency fluctuations (fALFF), which are key indices of brain functioning. However, ALFF and fALFF have been used only sporadically to study autism. rs-fMRI data from 69 children (40 autistic, mean age = 8.47 +/- 2.20 years; age range: 5.2 to 13.2; and 29 non-autistic, mean age = 9.02 +/- 1.97 years; age range 5.9 to 12.9) were obtained from the Autism Brain Imaging Data Exchange (ABIDE II). ALFF and fALFF were measured using CONN connectivity toolbox and SPM12, at whole-brain network-levels. A two-sampled t-test and a 2 Group (autistic, non-autistic) x 7 Networks ANOVA were conducted to test group differences in ALFF and fALFF. The whole-brain analysis identified significantly reduced ALFF values for autistic participants in left parietal opercular cortex, precuneus, and right insula. At the network level, there was a significant effect of diagnostic group and brain network on ALFF values, and only significant effect of network, not group, on fALFF values. Regression analyses indicated a significant effect of age on ALFF values of certain networks in autistic participants. Such intrinsically different network-level responses in autistic participants may have implications for task-level recruitment and synchronization of brain areas, which may in turn impact optimal cognitive functioning. Moreover, differences in low frequency fluctuations of key networks, such as the DMN and SN, may underlie alterations in brain responses in autism that are frequently reported in the literature.

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《Autism research :》 |2023年第1期|84-98|共15页
作者
Achuthan Smitha Karavallil; Coburn Kelly L.; Beckerson Meagan E.Kana Rajesh K.;
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作者单位

University of Alabama System,Univ Alabama;

Dept Speech Language Pathol & Audiol,Towson Univ;

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正文语种英语
中图分类神经病学与精神病学;
关键词
autism; default mode network; fractional amplitude of low frequency fluctuations; network level analysis; resting fMRI; whole brain analysis; DEFAULT MODE NETWORK; HIGH-FUNCTIONING AUTISM; SENTENCE COMPREHENSION; ORBITOFRONTAL CORTEX; NEURAL BASIS; CONNECTIVITY; BRAIN; UNDERCONNECTIVITY; ACTIVATION; ANATOMY;

Amplitude of low frequency fluctuations during resting state fMRI in autistic children

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