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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America. >Spatial organization of functional clusters representing reward and movement information in the striatal direct and indirect pathways
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Spatial organization of functional clusters representing reward and movement information in the striatal direct and indirect pathways

机译：Spatial organization of functional clusters representing reward and movement information in the striatal direct and indirect pathways

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摘要

To obtain insights into striatel neural processes underlying reward-based learning and movement control, we examined spatial organizations of striatel neurons related to movement and reward-based learning. For this, we recorded the activity of direct- and indirect-pathway neurons (D1 and A2a receptor-expressing neurons, respectively) in mice engaged in probabilistic classical conditioning and open-field free exploration. We found broadly organized functional clusters of striatel neurons in the direct as well as indirect pathways for both movement- and reward-related variables. Functional clusters for different variables were partially overlapping in both pathways, but the overlap between outcome- and value-related functional clusters was greater in the indirect than direct pathway. Also, value-related spatial clusters were progressively refined during classical conditioning. Our study shows the broad and learning-dependent spatial organization of functional clusters of dorsal striatel neurons in the direct and indirect pathways. These findings further argue against the classic model of the basal ganglia and support the importance of spatiotemporal patterns of striatel neuronal ensemble activity in the control of behavior.

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