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Role of club cell 16‐kDa secretory protein in asthmatic airways

机译：Role of club cell 16‐kDa secretory protein in asthmatic airways

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Abstract Background Club cell 16‐kDa secretory protein (CC16) is a pneumoprotein and functions as an anti‐inflammatory or antioxidant protein. However, altered levels of serum CC16 as well as their effect on airways inflammation have not been fully evaluated. Methods We recruited 63 adult asthmatics on maintenance medications and 61 healthy controls (HCs). The asthmatic subjects were divided into two groups according to the result of bronchodilator responsiveness (BDR) test: the present BDR (n?=?17) and absent BDR (n?=?46) groups. Serum CC16 levels were measured by ELISA. As an in vitro study, the effect of Dermatophagoides pteronyssinus antigen 1 (Der p1) on the production of CC16 in airways epithelial cells (AECs) according to a time‐dependent manner was assessed; the effects of CC16 protein on oxidative stress system, airways inflammation and remodelling were tested. Results Serum CC16 levels showed significantly higher in the asthmatics than in the HCs (p?

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