Erythrocytes, the most abundant cell type in the human body, are high bio-safety, hypoimmunogenic, flexibility, long cycling, and high drug loading. It was extensively studied as it can overcome many challenges in current conventional drug delivery systems. Up to now, there are many mature and feasible methods in reforming erythrocytes as drug carriers, which are mainly divided into the gene modification of erythrocytes, non-gene modification of erythrocytes and erythrocytemembrane modification of nano particles. This review focuses on the latest research progress on the reformed erythrocytes as drug nanocarriers. We also summarized the primary findings of reformed erythrocytes and outlooked future developing trends in reformed erythrocytes drug delivery system.
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