Background: The development and spread of pathogenic antibiotic resistance to many antibiotics have been growing worldwide. This concept is of enormous importance, and it is crucial to identify appropriate therapeutic drugs to fight against these antibiotic-resistant microbes. Plant species can make a valuable contribution to new antibiotics to replace or improve existing treatment potential. Methods: In this work, we conducted a molecular modelling study of three phytochemicals (Peperomin A, Peperomin E, Peperomin F) with bacterial targets penicillin-binding protein (2C6W) from Streptococcus pneumoniae and kdpFABC complex (5MRW) of Escherichia coli. Peperomia pellucida methanolic extract was conducted antimicrobial activity against clinical Streptococcus pneumoniae and Escherichia coli. Results: Three phytochemicals (Peperomin A, Peperomin E, Peperomin F) showed the best docking results with target antimicrobial-resistant targets. Peperomia pellucida methanolic extract showed good antibacterial activity against clinical Streptococcus pneumoniae and Escherichia coli. Conclusion: In-vitro and In silico bactericidal studies conducted, Peperomia pellucida phytochemical has significance antibacterial activity against clinical Streptococcus pneumoniae, Escherichia coli.
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