A new perspective on hippocampal synaptic plasticity and post‐stroke depression

Ning Sun; Wen‐Qiang Cui; Xiao‐Man MinGuang‐Ming ZhangJia‐Zheng LiuHong‐Yun Wu

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A new perspective on hippocampal synaptic plasticity and post‐stroke depression

机译：A new perspective on hippocampal synaptic plasticity and post‐stroke depression

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Abstract Post‐stroke depression, a common complication after stroke, severely affects the recovery and quality of life of patients with stroke. Owing to its complex mechanisms, post‐stroke depression treatment remains highly challenging. Hippocampal synaptic plasticity is one of the key factors leading to post‐stroke depression; however, the precise molecular mechanisms remain unclear. Numerous studies have found that neurotrophic factors, protein kinases and neurotransmitters influence depressive behaviour by modulating hippocampal synaptic plasticity. This review further elaborates on the role of hippocampal synaptic plasticity in post‐stroke depression by summarizing recent research and analysing possible molecular mechanisms. Evidence for the correlation between hippocampal mechanisms and post‐stroke depression helps to better understand the pathological process of post‐stroke depression and improve its treatment.

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来源
《The European journal of neuroscience.》 |2023年第4期|2961-2984|共24页
作者
Ning Sun; Wen‐Qiang Cui; Xiao‐Man MinGuang‐Ming ZhangJia‐Zheng LiuHong‐Yun Wu;
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作者单位

First College of Clinical Medicine,Shandong University of Traditional Chinese Medicine;

Department of Neurology,Affiliated Hospital of Shandong University of Traditional Chinese Medicine;

College of Chinese Medicine,Shandong University of Traditional Chinese Medicine;

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正文语种英语
中图分类神经病学与精神病学;
关键词
brain‐derived neurotrophic factor; Ca2+/calmodulin‐dependent protein kinase II; connexin 43; hippocampus; post‐stroke depression; synaptic plasticity;

A new perspective on hippocampal synaptic plasticity and post‐stroke depression

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