The costs and benefits of psychedelics on cognition and mood

Sayal Ceyda; Barrett Frederick S.

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The costs and benefits of psychedelics on cognition and mood

机译：The costs and benefits of psychedelics on cognition and mood

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Anecdotal evidence has indicated that psychedelic substances may acutely enhance creative task performance, although empirical support for this claim is mixed at best. Clinical research has shown that psychedelics might have enduring effects on mood and well-being. However, there is no neurocognitive framework that ties acute changes in cognition to long-term effects in mood. In this review, we operationalize creativity within an emerging cognitive control framework and assess the current empirical evidence of the effects of psychedelics on creativity. Next, we leverage insights about the mechanisms and computations by which other psychoactive drugs act to enhance versus impair cognition, in particular to those that act on catecholamines, the neurophysiological consequences of which are relatively well understood. Finally, we use the same framework to link the suggested psychedelic-induced improvements in creativity with enduring psychedelic-induced improvements in mood.

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《Neuron》 |2023年第5期|614-630|共17页
作者
Sayal Ceyda; Barrett Frederick S.;
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作者单位

Johns Hopkins University,Johns Hopkins Univ;

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原文格式 PDF
正文语种英语
中图分类神经病学;
关键词
MEDIAL PREFRONTAL CORTEX; SELF-CONTROL FAILURE; POSITIVE AFFECT; WORKING-MEMORY; PARKINSONS-DISEASE; CREATIVE-THINKING; PSYCHOLOGICAL FLEXIBILITY; EXTRACELLULAR DOPAMINE; INDIVIDUAL-DIFFERENCES; DIVERGENT THINKING;

The costs and benefits of psychedelics on cognition and mood

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