Characteristic retinal atrophy pattern allows differentiation between pediatric MOGAD and MS after a single optic neuritis episode

T.Pakeerathan; J.Havla; C.SchwakeA.SalmenS.BigiM.AbeggD.BrüggerT.FerrazziniA.-K.RungeM.BreuB.KornekG.BstehA.Felipe-RuciánM.RingelsteinO.AktasM.KarenfortE.WendelI.KleiterK.HellwigT.KümpfelC.ThielsT.LückeR.GoldK.RostasyI.Ayzenberg

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Characteristic retinal atrophy pattern allows differentiation between pediatric MOGAD and MS after a single optic neuritis episode

机译：Characteristic retinal atrophy pattern allows differentiation between pediatric MOGAD and MS after a single optic neuritis episode

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Abstract Background Optic neuritis (ON) is the most prevalent manifestation of pediatric multiple sclerosis (MSped) and myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGADped) in children?>?6?years. In this study, we investigated retinal atrophy patterns and diagnostic accuracy of optical coherence tomography (OCT) in differentiating between both diseases after the first ON episode.Methods Patients were retrospectively identified in eight tertial referral centers. OCT, VEP and high/low-contrast visual acuity (HCVA/LCVA) have been investigated?>?6?months after the first ON. Prevalence of pathological OCT findings was identified based on data of 144 age-matched healthy controls.Results Thirteen MOGADped (10.7?±?4.2?years, F:M 8:5, 21 ON eyes) and 21 MSped (14.3?±?2.4?years, F:M 19:2, 24 ON eyes) patients were recruited. We observed a significantly more profound atrophy of both peripapillary and macular retinal nerve fiber layer in MOGADped compared to MSped (pRNFL global: 68.2?±?16.9 vs. 89.4?±?12.3?μm, p?

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《Journal of neurology》 |2022年第12期|6366-6376|共11页
作者
T.Pakeerathan; J.Havla; C.SchwakeA.SalmenS.BigiM.AbeggD.BrüggerT.FerrazziniA.-K.RungeM.BreuB.KornekG.BstehA.Felipe-RuciánM.RingelsteinO.AktasM.KarenfortE.WendelI.KleiterK.HellwigT.KümpfelC.ThielsT.LückeR.GoldK.RostasyI.Ayzenberg;
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Department of Neurology, St. Josef-Hospital,Ruhr-University Bochum;

Institute of Clinical Neuroimmunology, LMU Hospital,Ludwig-Maximilians Universit?t München;

Department of Neuropediatrics, University Children’s Hospital,Ruhr-UniversityDepartment of Pediatric Neurology, Children’s Hospital Datteln,University Witten/HerdeckeDepartment of Neurology, Inselspital, Bern University Hospital,University of BernDepartment of Ophthalmology, Inselspital, Bern University Hospital,University of BernDivision of Pediatric Pulmonology, Allergology and Endocrinology, Department of Pediatrics andDepartment of Neurology,Medical University of ViennaDepartment of Pediatric Neurology,Universitat Autònoma de BarcelonaDepartment of Neurology, Medical Faculty,Heinrich-Heine-University DüsseldorfDepartment of General Paediatrics, Neonatology and Paediatric Cardiology,Heinrich-Heine-UniversityDepartment of Pediatric Neurology,Olgahospital;

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正文语种英语
中图分类神经病学;
关键词
Optical coherence tomography; Visual evoked potential; Optic neuritis; Myelin-oligodendrocyte-glycoprotein IgG; MOGAD; Multiple sclerosis; Pediatric patients; Children;

Characteristic retinal atrophy pattern allows differentiation between pediatric MOGAD and MS after a single optic neuritis episode

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