A Convolutional Neural Network Approach to Quantify Lung Disease Progression in Patients with Fibrotic Hypersensitivity Pneumonitis (HP)

Aliboni Lorenzo; Dias Olivia Meira; Baldi Bruno GuedesSawamura Marcio Valente YamadaChate Rodrigo CarusoCarvalho Carlos Roberto Ribeirode Albuquerque Andre Luis PereiraAliverti AndreaPennati Francesca

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A Convolutional Neural Network Approach to Quantify Lung Disease Progression in Patients with Fibrotic Hypersensitivity Pneumonitis (HP)

机译：A Convolutional Neural Network Approach to Quantify Lung Disease Progression in Patients with Fibrotic Hypersensitivity Pneumonitis (HP)

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Rationale and Objectives To evaluate associations between longitudinal changes of quantitative CT parameters and spirometry in patients with fibrotic hypersensitivity pneumonitis (HP). Materials and Methods Serial CT images and spirometric data were retrospectively collected in a group of 25 fibrotic HP patients. Quantitative CT analysis included histogram parameters (median, interquartile range, skewness, and kurtosis) and a pretrained convolutional neural network (CNN)-based textural analysis, aimed at quantifying the extent of consolidation (C), fibrosis (F), ground-glass opacity (GGO), low attenuation areas (LAA) and healthy tissue (H). Results At baseline, Ric was 61(44-70) pred. The median follow-up period was 1.4(0.8-3.2) years, with 3(2-4) visits per patient. Over the study, 8 patients (32) showed a FVC decline of more than 5, a significant worsening of all histogram parameters (p <= 0.015) and an increased extent of fibrosis via CNN (p=0.038). On histogram analysis, decreased skewness and kurtosis were the parameters most strongly associated with worsened FVC (respectively, r2=0.63 and r2=0.54, p<0.001). On CNN classification, increased extent of fibrosis and consolidation were the measures most strongly correlated with FVC decline (r2=0.54 and r2=0.44, p<0.001). Conclusion CT histogram and CNN measurements provide sensitive measures of functional changes in fibrotic HP patients over time. Increased fibrosis was associated with FVC decline, providing index of disease progression. CNN may help improve fibrotic HP follow-up, providing a sensitive tool for progressive interstitial changes, which can potentially contribute to clinical decisions for individualizing disease management.

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《Academic radiology》 |2022年第8期|E149-E156|共8页
作者
Aliboni Lorenzo; Dias Olivia Meira; Baldi Bruno GuedesSawamura Marcio Valente YamadaChate Rodrigo CarusoCarvalho Carlos Roberto Ribeirode Albuquerque Andre Luis PereiraAliverti AndreaPennati Francesca;
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作者单位

Polytechnic University of Milan,Politecn Milan;

Fac Med,Univ Sao Paulo;

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原文格式 PDF
正文语种英语
中图分类放射医学;
关键词
Computer-Assisted Image Analysis; Hypersensitivity Pneumonitis; Pulmonary Function Tests; Computed Tomography; Convolutional Neural Network; IDIOPATHIC PULMONARY-FIBROSIS; QUANTITATIVE CT INDEXES; COMPUTED-TOMOGRAPHY; AUTOMATED QUANTIFICATION; BASE-LINE; PATTERNS; DIAGNOSIS; SURVIVAL; EXTENT;

A Convolutional Neural Network Approach to Quantify Lung Disease Progression in Patients with Fibrotic Hypersensitivity Pneumonitis (HP)

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