• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Advanced functional materials >Drug Protein-Stabilized Biomimetic Amorphous Mineral Nanoparticles as Superior Drug Carriers
【24h】

Drug Protein-Stabilized Biomimetic Amorphous Mineral Nanoparticles as Superior Drug Carriers

机译：Drug Protein-Stabilized Biomimetic Amorphous Mineral Nanoparticles as Superior Drug Carriers

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相关主题

摘要

Minerals such as calcium carbonates and calcium phosphates are often usedas drug protein carriers, which are urgently required for drug protein-basedtherapy, due to their high biocompatibility. However, their performance isconstrained by some obstacles, such as the low loading capacity and shortcirculation half-life. Inspired by the in vivo growth of biominerals via thesoluble protein-stabilized amorphous precursors, herein drug proteins aredirectly used to stabilize amorphous carbonated calcium phosphate (ACCP)in a controlled mineralization environment. The bioactivity of the drugs in theACCP carrier is preserved due to the mild synthesis condition. The intrinsicallyhigh absorption capability of the ACCP nanoparticles (NPs) leads to an ultrahighprotein loading capacity. In addition, the amorphous nature of the carrierensures the homogeneous distribution of the protein molecules in the carrier,by which the drugs exhibit long-term release in vitro. The effectiveness of thisstrategy by the high osteogenic ability of insulin-like growth factor-1 loadedACCP NPs is demonstrated. Therefore, this biomimetic strategy provides apromising nanoplatform for drug protein-based applications.

著录项

获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号