Design of Solid-Contact Ion-Selective Electrode with Graphene Transducer Layer for the Determination of Flavoxate Hydrochloride in Dosage Form and in Spiked Human Plasma

Mahmoud Amr M.; Ragab Mona T.; Ramadan Nesrin K.El-Ragehy Nariman A.El-Zeany Badr A.

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Design of Solid-Contact Ion-Selective Electrode with Graphene Transducer Layer for the Determination of Flavoxate Hydrochloride in Dosage Form and in Spiked Human Plasma

机译：Design of Solid-Contact Ion-Selective Electrode with Graphene Transducer Layer for the Determination of Flavoxate Hydrochloride in Dosage Form and in Spiked Human Plasma

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Eco-friendly solid-contact ion selective electrode was fabricated and optimized for the determination of flavoxate hydrochloride in presence of its main metabolite. The process is based on carbon screen printed electrode and polyvinyl chloride polymeric sensing membrane. The first optimization step involved the ionophore selection through screening various ionophores, where calix4arene showed the highest affinity towards flavoxate. The second step, a graphene nanocomposite interlayer was employed as the ion-to-electron transducer between the carbon electrode and the polymeric ion sensing membrane. The graphene layer decreased the potential drift down to <500 mu V/h and improved the electrode stability.

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来源
《Electroanalysis》 |2020年第12期|2803-2811|共9页
作者
Mahmoud Amr M.; Ragab Mona T.; Ramadan Nesrin K.El-Ragehy Nariman A.El-Zeany Badr A.;
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作者单位

Cairo Univ, Dept Analyt Chem, Fac Pharm, Cairo 11562, Egypt;

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正文语种英语
中图分类电化学、电解、磁化学;
关键词
Calixarene; Flavoxate Hydrochloride; Graphene; Screen-Printed Electrodes; Solid-Contact Ion Selective Electrodes;

Design of Solid-Contact Ion-Selective Electrode with Graphene Transducer Layer for the Determination of Flavoxate Hydrochloride in Dosage Form and in Spiked Human Plasma

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