Protective Effect of Cerium Oxide Nanoparticles on Human Sperm Function During Cryopreservation

Maryam Hosseinmardi; Fatemeh Siadat; Mohsen SharafiNasim Hayati RoodbariMaryam Hezavehei

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Protective Effect of Cerium Oxide Nanoparticles on Human Sperm Function During Cryopreservation

机译：Protective Effect of Cerium Oxide Nanoparticles on Human Sperm Function During Cryopreservation

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The generation of reactive oxygen species during cryopreservation of human sperm has negative effects on the consistency of the thawed sperm. The antioxidant properties of cerium oxide nanoparticles (CeO2NPs) may be useful for reducing cryodamage in thawed sperm. This research was conducted to determine the effects of CeO2NPs on the quality and function of human sperm after thawing. Samples of semen obtained from 20 normozoospermic individuals were allocated to the following four groups: fresh, frozen control (sperm not treated with CeO2NPs), and those exposed to 0.1 μg/mL CeO2NPs (CeO2-0.1), 1 μg/mL CeO2NPs (CeO2-1), and 5 μg/mL CeO2NPs (CeO2-5). Sperm parameters of motility, viability, membrane integrity, DNA fragmentation, protamination, malondialdehyde (MDA) levels, mitochondria membrane potential, and morphology were evaluated after the freezing–thawing process. The results showed that 0.1 μg/mL CeO2NPs significantly (p 2-0.1 (3.06 ± 0.25 nmol/mL), CeO2-1 (3.1 ± 0.25 nmol/mL), and CeO2-5 (3.08 ± 0.25 nmol/mL) groups compared with the frozen control group (3.72 ± 0.25). Different concentrations of CeO2NPs did not significantly change sperm normal morphology and mitochondria activity (p < 0.05).

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《Biopreservation and biobanking》 |2022年第1期|24-30|共7页
作者
Maryam Hosseinmardi; Fatemeh Siadat; Mohsen SharafiNasim Hayati RoodbariMaryam Hezavehei;
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作者单位

Department of Developmental Biology, Faculty of Biology, Science and Research Branch, Islamic Azad University;

Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR;

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原文格式 PDF
正文语种英语
中图分类细胞生物学;
关键词
reactive oxygen species; DNA damage; nanoparticle; sperm cryopreservation;

Protective Effect of Cerium Oxide Nanoparticles on Human Sperm Function During Cryopreservation

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