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首页> 外文期刊>Autism research : >Pupillometric measures of altered stimulus‐evoked locus coeruleus‐norepinephrine activity explain attenuated social attention in preschoolers with autism spectrum disorder
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Pupillometric measures of altered stimulus‐evoked locus coeruleus‐norepinephrine activity explain attenuated social attention in preschoolers with autism spectrum disorder

机译：Pupillometric measures of altered stimulus‐evoked locus coeruleus‐norepinephrine activity explain attenuated social attention in preschoolers with autism spectrum disorder

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Abstract Attenuated social attention has been described as a reduced preference for social compared to geometric motion in preschoolers with autism spectrum disorder (ASD). The locus coeruleus‐norpinephrine (LC‐NE) system modulates sensory reactivity and is a promising underlying mechanism. LC‐NE activity is indexed by a stimulus‐evoked pupillary response (SEPR) and partially by a luminance‐adaptation pupillary response (LAPR), which were both shown to be aberrant in ASD. We examined whether SEPR and LAPR explain an attenuated social motion preference. We applied pupillometry via video‐based eye tracking in young children (18–65?months) with ASD (n?=?57) and typically developing (TD) children (n?=?39) during a preferential looking paradigm of competing social and geometric motion and a changing light condition paradigm. We found an attenuated social motion preference in the ASD compared to the TD group. This was accompanied by atypical pupillometry showing a smaller SEPR to social motion, a larger SEPR to geometric motion and a reduced LAPR to a dark screen. SEPR but not LAPR explained the group difference in social motion preference. An ASD diagnosis was statistically predicted by the social motion preference, while this effect was mediated by the inclusion of SEPR to geometric and social motion. Our findings suggest a decreased sensory reactivity to social and increased reactivity to non‐social motion in ASD, which may concurrently contribute to an attenuated social attention. The LC‐NE system is supported as a promising underlying mechanism of altered social attention in young children with ASD, while the specificity of findings remains to be addressed.

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