Microbiota regulation of viral infections through interferon signaling

Wirusanti Nurul I.; Baldridge Megan T.; Harris Vanessa C.

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Microbiota regulation of viral infections through interferon signaling

机译：Microbiota regulation of viral infections through interferon signaling

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The interferon (IFN) response is the major early innate immune response against invading viral pathogens and is even capable of mediating sterilizing antiviral immunity without the support of the adaptive immune system. Cumulative evi-dence suggests that the gut microbiota can modulate IFN responses, indirectly determining virological outcomes. This review outlines our current knowledge of the interactions between the gut microbiota and IFN responses and dissects the different mechanisms by which the gut microbiota may alter IFN expression to diverse viral infections. This knowledge offers a basis for translating experimental evidence from animal studies into the human context and identifies avenues for leveraging the gut microbiota-IFN-virus axis to improve control of viral infections and performance of viral vaccines.

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《Trends in Microbiology》 |2022年第8期|778-792|共15页
作者
Wirusanti Nurul I.; Baldridge Megan T.; Harris Vanessa C.;
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作者单位

Amsterdam Univ Med Ctr;

Washington Univ;

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原文格式 PDF
正文语种英语
中图分类微生物学;
关键词
HUMAN GUT MICROBIOME; BILE-ACIDS; IMMUNE-RESPONSES; III INTERFERONS; I INTERFERONS; ENTERIC VIRUS; COMMENSAL; INFLUENZA; IMPACT; POPULATIONS;

Microbiota regulation of viral infections through interferon signaling

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