Biomimetic Macrophage Membrane and Lipidated Peptide Hybrid Nanovesicles for Atherosclerosis Therapy

Linmiao Guo; Yunqiu Miao; Ying WangYing ZhangErfen ZhouJiangyue WangYanqi ZhaoLijun LiAohua WangYong GanXinxin Zhang

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Biomimetic Macrophage Membrane and Lipidated Peptide Hybrid Nanovesicles for Atherosclerosis Therapy

机译：Biomimetic Macrophage Membrane and Lipidated Peptide Hybrid Nanovesicles for Atherosclerosis Therapy

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Atherosclerosis is the underlying cause for cardiovascular disease.Current pharmacotherapies are limited by the inadequate targeting andinsufficient treatment. Herein, inspired by the interaction of macrophageand lipoprotein as a typical hallmark of atherosclerosis, hybridnanovesicles(MLP-NVs) are designed by fusion of anti-inflammatoryM2-phenotype macrophage membranes and lipidated peptide (DOPE-pp-HBSP) to mimic the binding manner of cell-lipoprotein for atherosclerotictreatment. Through hybridization of M2 macrophage membranes andlipidated peptide film, MLP-NVs facilitate the inflammatory cell internalizationat atherosclerotic site, and sequester the proinflammatorycytokines to suppress local inflammation. Moreover, MLP-NVs exhibit amatrix metalloprotease 2 (MMP2)-responsive release of the peptide HBSPin plaques, leading to the restoration of dysfunctional endothelial cells.In the ApoE?/? mice with atherosclerosis, simvastatin-loaded MLP-NVsprovide comprehensive treatment by inherent inflammation suppression,endothelial repair, and cholesterol efflux capacities, resulting in atheroscleroticplaques regression. Through closely mimicking physiologicalcues, this biomimetic hybrid nanovesicleplatform provides a potentialstrategy for anti-atherosclerotic therapy.

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《Advanced functional materials》 |2022年第51期|2204822.1-2204822.15|共15页
作者
Linmiao Guo; Yunqiu Miao; Ying WangYing ZhangErfen ZhouJiangyue WangYanqi ZhaoLijun LiAohua WangYong GanXinxin Zhang;
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State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203, P. R. China;

School of PharmacyUniversity of Chinese Academy of SciencesBeijing 100049, P. R. China;

Shanghai Tenth People’s Hospital, School of MedicineTongji UniversityShanghai 200072, P. R. China;

School of Chinese Materia MedicaNanjing University of Chinese MedicineNanjing 210046, P. R. ChinaState Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203, P. R. ChinaSchool of PharmacyUniversity of Chinese Academy of SciencesBeijing 100049, P. R. ChinaState Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203, P. R. China;

School of PharmacyUniversity of Chinese Academy of SciencesBeijing 100049, P. R. China;

Shanghai Tenth People’s Hospital, Schoo;

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atherosclerosis; biomimetic nanovesicles; comprehensive therapies; lipidated peptides; macrophage membranes;

Biomimetic Macrophage Membrane and Lipidated Peptide Hybrid Nanovesicles for Atherosclerosis Therapy

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