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Therapeutic application of genome editing in dyslipidemia

机译:Therapeutic application of genome editing in dyslipidemia

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Purpose of review To summarize recent advances with respect to the use of genome editing to modify blood lipid levels in vivo . Recent findings Genome-editing technologies have been successfully used to target the PCSK9 gene in the livers of nonhuman primates and significantly reduce blood LDL cholesterol levels. Summary Multiple proof-of-concept nonhuman primate studies raise the prospect of genome editing empowering ‘one-and-done’ therapies for the treatment of dyslipidemic patients.

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