The role of GPLD1 in chronic diseases

Jing Cao; Anni Zhou; Zhuoyang ZhouHui LiuShaohui Jia

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The role of GPLD1 in chronic diseases

机译：The role of GPLD1 in chronic diseases

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Abstract Glycosylphosphatidylinositol‐specific phospholipase D (GPLD1) is a specific enzyme for glycosylphosphatidylinositol (GPI) anchors, thereby exerting its biological functions by cleaving membrane‐associated GPI molecules. GPLD1 is abundant in serum, with a concentration of approximately 5?10?μg/mL. Previous studies have demonstrated that GPLD1 plays a crucial role in the pathogenesis of numerous chronic diseases including disorders of lipid and glucose metabolism, cancer, and neurological disorders. In the present study, we reviewed the structure, functions, and localization of GPLD1 in chronic diseases, as well as exercise‐mediated regulation of GPLD1, thus providing a theoretical support to develop GPLD1 as a new therapeutic target for chronic diseases.

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《Journal of cellular physiology.》 |2023年第7期|1407-1415|共9页
作者
Jing Cao; Anni Zhou; Zhuoyang ZhouHui LiuShaohui Jia;
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作者单位

School of Physical Education,Jinan University;

Hubei Key Laboratory of Sport Training and Monitoring,?Tianjiu Research and Development Center for;

Graduate School of Wuhan Sports University;

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原文格式 PDF
正文语种英语
中图分类细胞生物学;
关键词
cancer; exercise; glucose metabolic diseases; GPLD1; nervous system diseases;

The role of GPLD1 in chronic diseases

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