In Vivo Evolution of CTX-M-215, a Novel Narrow-Spectrum beta-Lactamase in an Escherichia coli Clinical Isolate Conferring Resistance to Mecillinam

Yin Mengyun; Hu Guoping; Shen ZhenFang ChengliZhang XuefeiLi DanDoi YoheiZhang YuWang MingguiGuo Qinglan

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In Vivo Evolution of CTX-M-215, a Novel Narrow-Spectrum beta-Lactamase in an Escherichia coli Clinical Isolate Conferring Resistance to Mecillinam

机译：In Vivo Evolution of CTX-M-215, a Novel Narrow-Spectrum beta-Lactamase in an Escherichia coli Clinical Isolate Conferring Resistance to Mecillinam

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Here, we report a novel narrow-spectrum beta-lactamase CTX-M-215 identified in an Escherichia coli clinical isolate in China and conferring high-level resistance to mecillinam but not to cefotaxime. CTX-M-215 differed from CTX-M-125, a CTX-M extended-spectrum beta-lactamase (ESBL), by an N132D substitution, which decreased hydrolytic activities toward penicillins and cephalosporins except for mecillinam. High similarity was observed between CTX-M-215- and CTX-M-125-bearing plasmids, carried by different isolates in the same patient, indicating in vivo evolution of CTX-M-215 from CTX-M-125.

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《Antimicrobial agents and chemotherapy.》 |2020年第11期|共6页
作者
Yin Mengyun; Hu Guoping; Shen ZhenFang ChengliZhang XuefeiLi DanDoi YoheiZhang YuWang MingguiGuo Qinglan;
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作者单位

Fudan Univ, Huashan Hosp, Inst Antibiot, Shanghai, Peoples R China;

WuXi AppTec Co Ltd, Shanghai, Peoples R China;

Shanghai Jiao Tong Univ, Renji Hosp, Dept Lab, Shanghai, Peoples R ChinaChinese Acad Sci, Key Lab Synthet Biol, Shanghai, Peoples R ChinaUniv Pittsburgh, Sch Med, Div Infect Dis, Pittsburgh, PA USA;

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原文格式 PDF
正文语种英语
中图分类治疗学;
关键词
narrow-spectrum beta-lactamase; CTX-M-type enzyme; mecillinam; cefotaxime; N132D;

In Vivo Evolution of CTX-M-215, a Novel Narrow-Spectrum beta-Lactamase in an Escherichia coli Clinical Isolate Conferring Resistance to Mecillinam

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