...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental Science & Technology: ES&T >Prenatal Exposure of Organophosphate Esters and Its Trimester-Specific and Gender-Specific Effects on Fetal Growth
【24h】

Prenatal Exposure of Organophosphate Esters and Its Trimester-Specific and Gender-Specific Effects on Fetal Growth

机译：Prenatal Exposure of Organophosphate Esters and Its Trimester-Specific and Gender-Specific Effects on Fetal Growth

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相关主题

摘要

The toxicity of organophosphate esters(OPEs)on embryonic development is well noted in animal experiments,but epidemiological studies are still lacking.This study evaluated the prenatal exposure of OPEs and its trimester-specific and gender-specific effects on fetal growth.The correlations between OPE exposure and fetal growth were investigated by linear mixed-effect models and multivariable linear regression analyses.Prenatal exposure to tributyl phosphate(TBP)was negatively associated with a z-score of fetal abdominal circumference(AC),biparietal diameter(BPD),femur length(FL),and head circumference(HC).In the second trimester,the serum concentration of TBP was inversely related to the z-score of AC,BPD,and HC.In the third trimester,serum concentration of TBP was inversely related to AC,BPD,and FL z-scores.Prenatal exposure to tri-m-cresyl phosphate(TMCP)was inversely related to the z-score of AC,BPD,and HC.In the second trimester,TMCP was negatively correlated with AC,BPD,FL,and HC z-scores.After stratification by gender,male fetuses were more sensitive to OPE exposure.The above results remained robust after excluding pregnant women who gave preterm birth or those with low or high pre-pregnancy BMI.Our findings suggested that health effects of typical OPEs,particularly TBP and TMCP,should be taken into consideration in future works.

著录项

获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号