Neuroprotective Potential of Bacopa monnieri : Modulation of Inflammatory Signals

Erica Costantini; Srinivas Jarlapoodi; Federica SerraLisa AielliHaroon KhanTarun BelwalKatia FalascaMarcella Reale

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Neuroprotective Potential of Bacopa monnieri : Modulation of Inflammatory Signals

机译：Neuroprotective Potential of Bacopa monnieri : Modulation of Inflammatory Signals

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Background: To date, much evidence has shown the increased interest in natural molecules and traditional herbal medicine as alternative bioactive compounds to fight many inflammatory conditions, both in relation to immunomodulation and in terms of their wound healing potential. Bacopa monnieri is a herb that is used in the Ayurvedic medicine tradition for its anti-inflammatory activity. Objective: In this study, we evaluate the anti-inflammatory and regenerative properties of the Bacopa monnieri extract (BME) in vitro model of neuroinflammation. Methods: Neuronal SH-SY5Y cells were stimulated with TNFα and IFNγ and used to evaluate the effect of BME on cell viability, cytotoxicity, cytokine gene expression, and healing rate. Results: Our results showed that BME protects against the Okadaic acid-induced cytotoxicity in SH-SY5Y cells. Moreover, in TNFα and IFNγ primed cells, BME reduces IL-1β, IL-6, COX-2, and iNOS, mitigates the mechanical trauma injury-induced damage, and accelerates the healing of wounds. Conclusion: This study indicates that BME might become a promising candidate for the treatment of neuroinflammation.

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《CNS & neurological disorders drug targets》 |2023年第3期|441-451|共11页
作者
Erica Costantini; Srinivas Jarlapoodi; Federica SerraLisa AielliHaroon KhanTarun BelwalKatia FalascaMarcella Reale;
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University “G.d’Annunzio”,,Department of Medicine and Science of Aging,Via dei Vestini, 66100;

University “G.d’Annunzio”,Department of Innovative Technologies in Medicine and Dentistry,Via dei;

University “G.d’Annunzio”,,Department of Pharmacy,,Via dei Vestini, 66100 Chieti,Chieti,Italy,66100,University “G.d’Annunzio”,,Department of Innovative Technologies in Medicine and Dentistry,Via deiAbdul Wali Khan University,Department of Pharmacy,Mardan,Pakistan,23200,Zhejiang University,College of Biosystems Engineering and Food Science,,Hangzhou,China,310058,University “G.d’Annunzio”,Department of Medicine and Science of Aging,Via dei Vestini, 66100 Chieti;

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正文语种英语
中图分类神经病学与精神病学;
关键词
Neuroprotection; inflammation; cytokines; metalloproteinases; cyclooxygenase; inducible nitric oxide synthase.;

Neuroprotective Potential of Bacopa monnieri : Modulation of Inflammatory Signals

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