2-Methyltetrahydrofuran (2-MeTHF) as a versatile green solvent for the synthesis of amphiphilic copolymers via ROP, FRP, and RAFT tandem polymerizations

Englezou Georgia; Kortsen Kristoffer; Pacheco Ana A. C.Cavanagh RobertLentz Joachim C.Krumins EduardsSanders-Velez CarlosHowdle Steven M.Nedoma Alisyn J.Taresco Vincenzo

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2-Methyltetrahydrofuran (2-MeTHF) as a versatile green solvent for the synthesis of amphiphilic copolymers via ROP, FRP, and RAFT tandem polymerizations

机译：2-Methyltetrahydrofuran (2-MeTHF) as a versatile green solvent for the synthesis of amphiphilic copolymers via ROP, FRP, and RAFT tandem polymerizations

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2-methyltetrahydrofuran (2-MeTHF) is a readily available, inexpensive, neoteric, bio-based solvent. It has been adopted across a wide range of chemical processes including the batch manufacture of fine chemicals, enzymatic polycondensations and ring opening polymerizations. To reduce the environmental burden related to the synthesis of pharmaceutical-grade polymers based on lactide and caprolactone, we envisaged the use of 2-MeTHF. For the first time, we combined a series of metal-free and enzymatic ROPs with free radical and controlled RAFT polymerizations (carried out separately and in tandem) in 2-MeTHF, in order to easily tune the chemistry and the architecture of the final polymers. After a simple purification, the amphiphilic polymers were formulated into nanoparticles and tested for their cytocompatibility in three model cell lines, to assess their application as potential polymeric excipients for nanomedicines.

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《Journal of Polymer Science》 |2020年第11期|1571-1581|共11页
作者
Englezou Georgia; Kortsen Kristoffer; Pacheco Ana A. C.Cavanagh RobertLentz Joachim C.Krumins EduardsSanders-Velez CarlosHowdle Steven M.Nedoma Alisyn J.Taresco Vincenzo;
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作者单位

Univ Sheffield, Dept Chem & Biol Engn, Sir Robert Hadfield Bldg, Sheffield S1 3JD, S Yorkshire, England;

Univ Nottingham, Sch Chem, Univ Pk, Nottingham NG7 2RD, England;

Univ Nottingham, Sch Pharm, Nottingham, England;

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正文语种英语
中图分类有机化学;高分子化学（高聚物）;
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2-MeTHF; green solvent; organo-enzymatic ROP; ROP-free radical tandem polymerizations; ROP-RAFT tandem polymerizations;

2-Methyltetrahydrofuran (2-MeTHF) as a versatile green solvent for the synthesis of amphiphilic copolymers via ROP, FRP, and RAFT tandem polymerizations

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