The BEEHAVE_(ecotox) Model—Integrating a Mechanistic Effect Module into the Honeybee Colony Model

Thomas G. Preuss; Annika Agatz; Benoit GoussenVanessa RoebenJack RumkeeLiubov ZakharovaPernille Thorbek

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The BEEHAVE_(ecotox) Model—Integrating a Mechanistic Effect Module into the Honeybee Colony Model

机译：The BEEHAVE_(ecotox) Model—Integrating a Mechanistic Effect Module into the Honeybee Colony Model

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Mechanistic effect models are powerful tools for extrapolating from laboratory studies to field conditions. For bees,several good models are available that can simulate colony dynamics. Controlled and reliable experimental systems are alsoavailable to estimate the inherent toxicity of pesticides to individuals. However, there is currently no systematic andmechanistic way of linking the output of experimental ecotoxicological testing to bee models for bee risk assessment. Weintroduce an ecotoxicological module that mechanistically links exposure with the hazard profile of a pesticide for individualhoneybees so that colony effects emerge. This mechanistic link allows the translation of results from standard laboratorystudies to relevant parameters and processes for simulating bee colony dynamics. The module was integrated into the stateof‐the‐art honeybee model BEEHAVE. For the integration, BEEHAVE was adapted to mechanistically link the exposure andeffects on different cohorts to colony dynamics. The BEEHAVEecotox model was tested against semifield (tunnel) studies,which were deemed the best study type to test whether BEEHAVE（ecotox） predicted realistic effect sizes under controlledconditions. Two pesticides used as toxic standards were chosen for this validation to represent two different modes of action:acute mortality of foragers and chronic brood effects. The ecotoxicological module was able to predict effect sizes in thetunnel studies based on information from standard laboratory tests. In conclusion, the BEEHAVEecotox model is an excellenttool to be used for honeybee risk assessment, interpretation of field and semifield studies, and exploring the efficiency ofdifferent mitigation measures. The principles for exposure and effect modules are portable and could be used for any wellconstructedhoneybee model.

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《Environmental toxicology and chemistry /》 |2022年第11期|2870-2882|共13页
作者
Thomas G. Preuss; Annika Agatz; Benoit GoussenVanessa RoebenJack RumkeeLiubov ZakharovaPernille Thorbek;
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作者单位

Institute for Biological Analytics & Consulting, Ro?dorf, Germany;

Bayer, Monheim am Rhein, Germany;

Syngenta, Bracknell, Berkshire, United KingdomBASF SE, Limburgerhof, Germany;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
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Ecotoxicology; honeybee; pesticides; population modeling; risk assessment;

The BEEHAVE_(ecotox) Model—Integrating a Mechanistic Effect Module into the Honeybee Colony Model

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