Comprehensive review on molnupiravir in COVID-19: a novel promising antiviral to combat the pandemic

Khiali Sajad; Khani Elnaz; B Rouy SaminehEntezari-Maleki Taher

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Comprehensive review on molnupiravir in COVID-19: a novel promising antiviral to combat the pandemic

机译：Comprehensive review on molnupiravir in COVID-19: a novel promising antiviral to combat the pandemic

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Despite the progress in the management of COVID-19, effective oral antiviral agents are still lacking. In the present review, the potential beneficial effects of molnupiravir in the management of COVID-19 are discussed. A literature search in Google Scholar, Scopus, PubMed and clinicaltrials.gov for the relevant articles regarding the pharmacokinetics, pharmacodynamics and clinical trials of molnupiravir in the management of COVID-19 is conducted. Most of the preclinical studies and available clinical trials showed a favorable short-term safety profile of molnupiravir; however, given its possible genotoxic effects, further trials are required to confirm the long-term efficacy and safety of molnupiravir in patients with COVID-19.

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来源
《Future microbiology》 |2022年第5期|377-391|共15页
作者
Khiali Sajad; Khani Elnaz; B Rouy SaminehEntezari-Maleki Taher;
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作者单位

Dept Clin Pharm,Tabriz Univ Med Sci;

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原文格式 PDF
正文语种英语
中图分类微生物学;
关键词
COVID-19; direct-acting antivirals; molnupiravir; MK-4482; SARS-CoV-2; VIRAL LOAD; THERAPY; REPLICATION; SARS-COV-2; INFECTION; VACCINES; VIRUSES;

Comprehensive review on molnupiravir in COVID-19: a novel promising antiviral to combat the pandemic

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