Bivalent hemagglutinin and neuraminidase influenza replicon particle vaccines protect pigs against influenza a virus without causing vaccine associated enhanced respiratory disease

Brand Meghan Wymore; Anderson Tavis K.; Kitikoon PravinaKimble J. BrianOtis NicholasGauger Phillip C.Souza Carine K.Kaplan BryanMogler MarkStrait ErinBaker Amy L. Vincent

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Bivalent hemagglutinin and neuraminidase influenza replicon particle vaccines protect pigs against influenza a virus without causing vaccine associated enhanced respiratory disease

机译：Bivalent hemagglutinin and neuraminidase influenza replicon particle vaccines protect pigs against influenza a virus without causing vaccine associated enhanced respiratory disease

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Alphavirus-derived RNA replicon particle (RP) vaccines represent the next generation of swine influenza A virus (IAV) vaccines, as they were shown to be safe, effective, and offer advantages over traditional vaccine platforms. IAV is a significant respiratory pathogen of swine and there is a critical need to improve current commercial swine IAV vaccine platforms. Adjuvanted whole inactivated virus (WIV) IAV swine vaccines provide limited heterologous protection and may lead to vaccine-associated enhanced respiratory disease (VAERD). This study investigated the ability of RP IAV hemagglutinin (HA) vaccines to avoid VAERD and evaluated experimental multivalent HA and neuraminidase (NA) RP vaccines. RP vaccines were formulated with HA or NA heterologous or homologous to the challenge virus in monovalent HA or HA and NA bivalent combinations (HA/NA bivalent). Pigs were vaccinated with an HA RP, HA/NA bivalent RP, or heterologous HA WIV, followed by IAV challenge and necropsy 5 days post infection. RP vaccines provided homologous protection from challenge and induced robust peripheral and local antibody responses. The RP vaccine did not induce VAERD after challenge with a virus containing the heterologous HA, in contrast to the traditional WIV vaccine. The HA monovalent and HA/NA bivalent RP vaccines showed superior protection compared to traditional WIV. Additionally, the RP platform allows greater flexibility to adjust HA and NA content to reflect circulating IAV in swine antigenic diversity.Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creative-commons.org/licenses/by-nc-nd/4.0/).

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《Vaccine》 |2022年第38期|5569-5578|共10页
作者
Brand Meghan Wymore; Anderson Tavis K.; Kitikoon PravinaKimble J. BrianOtis NicholasGauger Phillip C.Souza Carine K.Kaplan BryanMogler MarkStrait ErinBaker Amy L. Vincent;
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作者单位

USDA ARS;

Merck Anim Hlth;

Iowa State Univ;

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原文格式 PDF
正文语种英语
中图分类医学免疫学;
关键词
Influenza; Swine; Replicon particle; RNA vaccine; Vaccine Associated Enhanced Respiratory; Disease (VAERD); ANTIBODIES; INFECTION; CHALLENGE; ASSAY; EFFICACY;

Bivalent hemagglutinin and neuraminidase influenza replicon particle vaccines protect pigs against influenza a virus without causing vaccine associated enhanced respiratory disease

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