Biological embedding of experience: A primer on epigenetics

Aristizabal Maria J.; Anreiter Ina; Halldorsdottir ThorhildurOdgers Candice L.McDade Thomas W.Goldenberg AnnaMostafavi SaraKobor Michael S.Binder Elisabeth B.Sokolowski Marla B.ODonnell Kieran J.

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Biological embedding of experience: A primer on epigenetics

机译：Biological embedding of experience: A primer on epigenetics

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摘要

Biological embedding occurs when life experience alters biological processes to affect later life health and well-being. Although extensive correlative data exist supporting the notion that epigenetic mechanisms such as DNA methylation underlie biological embedding, causal data are lacking. We describe specific epigenetic mechanisms and their potential roles in the biological embedding of experience. We also consider the nuanced relationships between the genome, the epigenome, and gene expression. Our ability to connect biological embedding to the epigenetic landscape in its complexity is challenging and complicated by the influence of multiple factors. These include cell type, age, the timing of experience, sex, and DNA sequence. Recent advances in molecular profiling and epigenome editing, combined with the use of comparative animal and human longitudinal studies, should enable this field to transition from correlative to causal analyses.

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《Proceedings of the National Academy of Sciences of the United States of America.》 |2020年第38期|23261-23269|共9页
作者
Aristizabal Maria J.; Anreiter Ina; Halldorsdottir ThorhildurOdgers Candice L.McDade Thomas W.Goldenberg AnnaMostafavi SaraKobor Michael S.Binder Elisabeth B.Sokolowski Marla B.ODonnell Kieran J.;
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作者单位

Dept Ecol & Evolutionary Biol,Univ Toronto;

Fac Med,Univ Iceland;

CIFAR,MaRS CtrCtr Mol Med & Therapeut,Univ British Columbia;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
epigenetic mechanisms; gene-environment interplay; biological embedding of experience; epigenome; translational research; POSTTRAUMATIC-STRESS-DISORDER; LONG NONCODING RNAS; DNA METHYLATION; PREFRONTAL CORTEX; MATERNAL-CARE; MENTAL-HEALTH; LIFE STRESS; CHROMATIN; GENOME; MECHANISMS;

Biological embedding of experience: A primer on epigenetics

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